Renin Inhibitors in Foodstuffs: Structure-Function Relationship

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Renin Inhibitors in Foodstuffs: Structure-Function Relationship

Renin, a highly specific aspartic proteinase originated from kidney, is a ratelimiting enzyme in renin-angiotensin system. Recently, we developed effective expression system for recombinant human (rh) renin using baculovirus-insect cell expression system, and simple and rapid assay method for rh-renin using internally quenched fluorogenic (IQF) substrate. Using the purified rh-renin and the IQF...

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Structure and function of renin binding protein.

Renin binding protein (RnBP) is a proteinous renin inhibitor. This protein binds to renin forming a protein complex, so-called high molecular weight (HMW) renin. The protein complex has been confirmed by purification and characterization of HMW renin [1] and RnBP from porcine kidney [2, 31. Recently, cDNA clones encoding RnBPs were isolated from porcine, human and rat kidney cDNA libraries [4, ...

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Human renin inhibitors.

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Structure-Function Relationship of Metalloproteins

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Structure-Function Relationship of Metalloproteins

Metalloproteins are a class of biologically important macromolecules, which have various functions such as oxygen transport, electron transfer, oxidation, and oxygenation. These diverse functions of metalloproteins have been thought to depend on the ligands from amino acid, coordination structures, and protein structures in immediate vicinity of metal ions. In this project, we are studying the ...

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ژورنال

عنوان ژورنال: Journal of Biological Macromolecules

سال: 2014

ISSN: 1347-2194,2187-3240

DOI: 10.14533/jbm.14.71